Characterization of MeCP2e1 Transgenic Mice


Rett Syndrome (RTT), a neurodevelopmental disorder characterized by loss of speech and purposeful limb movement, seizures, breathing abnormalities, and often autistic features, is caused by mutations in methyl CpG binding protein 2 (MeCP2). In 2004, a second isoform of MeCP2, called MeCP2e1, was discovered. While MeCP2e1 appears to be the predominant… (More)