Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA.

@article{Meehan1992CharacterizationOM,
  title={Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA.},
  author={Richard R. Meehan and Joe D. Lewis and Adrian Bird},
  journal={Nucleic acids research},
  year={1992},
  volume={20 19},
  pages={
          5085-92
        }
}
Methylated DNA in vertebrates is associated with transcriptional repression and inactive chromatin. Two activities have been identified, MeCP1 and MeCP2, which bind specifically to DNA containing methyl-CpG pairs. In this report we characterize MeCP2. We show that it is more abundant than MeCP1, is more tightly bound in the nucleus, and is distinguishable chromatographically. The two proteins share widespread expression in somatic mammalian cells, and barely detectable expression in early… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 208 CITATIONS, ESTIMATED 66% COVERAGE

Department of Molecular Medicine, National Public Health Institute

Leena Peltonen-Palotie, Docent Irma Järvelä
  • 2002
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

DNA methylation in fibrosis.

  • European journal of cell biology
  • 2016
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing.

VIEW 4 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Recent advances in MeCP2 structure and function.

  • Biochemistry and cell biology = Biochimie et biologie cellulaire
  • 2009
VIEW 5 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Aberrant DNA methylation as a cancer-inducing mechanism.

  • Annual review of pharmacology and toxicology
  • 2005
VIEW 19 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1992
2019

CITATION STATISTICS

  • 21 Highly Influenced Citations

  • Averaged 8 Citations per year from 2017 through 2019

Similar Papers