Characterization of Matrix Metalloproteinase-8 (MMP-8) Structure and Stability and the Effects of Its Interaction with the Inhibitory Metal Abstraction Peptide NCC Using High-Resolution Solution NMR

Abstract

Matrix metalloproteinases (MMPs) are important enzymes for extracellular matrix degradation. Cleavage of collagen by MMP-8 is an important regulator of tissue remodeling in wound healing and repair, but it also contributes to the exacerbation of several inflammatory diseases and can serve a protective role in early stages of cancer. In addition through its… (More)

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