Characterization of Mammalian Selenoproteomes

  title={Characterization of Mammalian Selenoproteomes},
  author={Gregory V. Kryukov and Sergio Castellano and Sergey V. Novoselov and Alexey V. Lobanov and Omid Zehtab and Roderic Guig{\'o} and Vadim N. Gladyshev},
  pages={1439 - 1443}
In the genetic code, UGA serves as a stop signal and a selenocysteine codon, but no computational methods for identifying its coding function are available. Consequently, most selenoprotein genes are misannotated. We identified selenoprotein genes in sequenced mammalian genomes by methods that rely on identification of selenocysteine insertion RNA structures, the coding potential of UGA codons, and the presence of cysteine-containing homologs. The human selenoproteome consists of 25… 
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