Characterization of MS-857, a New and Potent Cardiotonic Agent, in Isolated Mammalian Cardiac Muscles

  title={Characterization of MS-857, a New and Potent Cardiotonic Agent, in Isolated Mammalian Cardiac Muscles},
  author={Joji Kamiya and Masahiko Maruyama and Koichi Kawai and Takashi Kobari},
  journal={Journal of Cardiovascular Pharmacology},
Summary: The positive inotropic activity of MS-857, a novel cardiotonic agent, was assessed in isolated atrial and ventricular muscle of several mammalian species. MS-857 (0.1–300 μM) increased the developed tension of the dog, rabbit, monkey, cat, and guinea pig ventricular muscles in a concentration-dependent manner. However, MS-857 failed to cause a positive inotropic effect in isolated rat ventricular muscle. In isolated guinea pig atria, MS-857 caused both positive inotropic and… 

Relationship between the structure and effects of cardiotonics with nonglycoside and noncatecholamine structure

Cardiotonic agents, including cardiac glycosides and catecholamines, are used for CCI treatment, characterized by narrow therapeutic latitude, cardioand nephrotoxicity, nonuniform absorption, etc.

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The present study identified and characterize the isoenzymes of cyclic nucleotide phosphodiesterase (PDE) and to determine their intracellular distribution in human kidney and heart and resolved one form of cAMP-PDEβ, newly recognized in human tissues.

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