Characterization of MS-857, a New and Potent Cardiotonic Agent, in Isolated Mammalian Cardiac Muscles

  title={Characterization of MS-857, a New and Potent Cardiotonic Agent, in Isolated Mammalian Cardiac Muscles},
  author={J. Kamiya and M. Maruyama and K. Kawai and T. Kobari},
  journal={Journal of Cardiovascular Pharmacology},
Summary: The positive inotropic activity of MS-857, a novel cardiotonic agent, was assessed in isolated atrial and ventricular muscle of several mammalian species. MS-857 (0.1–300 μM) increased the developed tension of the dog, rabbit, monkey, cat, and guinea pig ventricular muscles in a concentration-dependent manner. However, MS-857 failed to cause a positive inotropic effect in isolated rat ventricular muscle. In isolated guinea pig atria, MS-857 caused both positive inotropic and… Expand
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