Characterization of MHC class I restricted cytotoxic T cell responses to tax in HTLV-1 infected patients with neurologic disease.

@article{Koenig1993CharacterizationOM,
  title={Characterization of MHC class I restricted cytotoxic T cell responses to tax in HTLV-1 infected patients with neurologic disease.},
  author={Scott Koenig and Robert M. Woods and Yambasu A. Brewah and Andrew J. Newell and Gary M. Jones and Elke Boone and Joseph W. Adelsberger and Michael W. Baseler and S. M. Robinson and Steven Jacobson},
  journal={Journal of immunology},
  year={1993},
  volume={151 7},
  pages={3874-83}
}
To understand the nature of the cytotoxic T cell response generated in human T lymphotropic virus type 1 (HTLV-1)-infected patients with HTLV-1-associated myelopathy/tropical spastic paraparesis, we cloned CTL from the peripheral blood and cerebrospinal fluid from patients with neurologic diseases and demonstrated the presence of HLA-A2, A3, and B14 restricted responses to the HTLV-1 p40x (tax) protein. We identified the minimal amino acid residues within the epitopes required for binding and… CONTINUE READING
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