Characterization of Lipid Bilayers and Protein Assemblies Supported on Rough Surfaces by Atomic Force Microscopy

  title={Characterization of Lipid Bilayers and Protein Assemblies Supported on Rough Surfaces by Atomic Force Microscopy},
  author={R. Richter and A. Brisson},
Supported lipid bilayers (SLBs) and two-dimensional protein assemblies formed on solid supports of various roughnesses were characterized by atomic force microscopy (AFM). The presence of SLBs was detected reliably by force measurements and by imaging. Three types of responses could be distinguished depending on the applied loads. These responses are interpreted as due to transient restructuration of the lipid assembly in the region of contact between lipid-covered support and AFM tip, driven… Expand

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