Characterization of Ligand Binding by Saturation Transfer Difference NMR Spectroscopy.

  title={Characterization of Ligand Binding by Saturation Transfer Difference NMR Spectroscopy.},
  author={Moriz Mayer and Bernd Meyer},
  journal={Angewandte Chemie},
  volume={38 12},
Fast identification of binding activity directly from mixtures of potential ligands is possible with the NMR method described, which is based on saturation transfer to molecules in direct contact to a protein. In addition, the ligand's binding epitope is easily identified. High sensitivity and ease of use are the principal advantages of this method. The picture shows the normal 1D NMR spectrum of a mixture and the spectrum obtained by applying the STD method, which exclusively shows signals… CONTINUE READING
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