Characterization of Lgr5+ progenitor cell transcriptomes in the apical and basal turns of the mouse cochlea

@inproceedings{Waqas2016CharacterizationOL,
  title={Characterization of Lgr5+ progenitor cell transcriptomes in the apical and basal turns of the mouse cochlea},
  author={Muhammad Waqas and Luo Guo and Shasha Zhang and Yan Chen and Xingang Zhang and Lei Wang and Mingliang Tang and Haibo Shi and Phillip I Bird and Huawei Li and Renjie Chai},
  booktitle={Oncotarget},
  year={2016}
}
Lgr5+ supporting cells (SCs) are enriched hair cell (HC) progenitors in the cochlea, and several studies have shown a difference in the proliferation and HC regeneration ability of SCs between the apical and basal turns. However, the detailed differences between the transcriptomes of the apical and basal Lgr5+ SCs have not yet been investigated. We found that when isolated by FACS, Lgr5+ cells from the apex generated significantly more HCs and had significantly higher proliferation and mitotic… CONTINUE READING
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