Characterization of Leishmania major phosphatidylethanolamine methyltransferases LmjPEM1 and LmjPEM2 and their inhibition by choline analogs.

@article{Bibis2014CharacterizationOL,
  title={Characterization of Leishmania major phosphatidylethanolamine methyltransferases LmjPEM1 and LmjPEM2 and their inhibition by choline analogs.},
  author={Stergios S. Bibis and K. Dahlstrom and T. Zhu and R. Zufferey},
  journal={Molecular and biochemical parasitology},
  year={2014},
  volume={196 2},
  pages={
          90-9
        }
}
Phosphatidylcholine (PC) is the most abundant phospholipid in the membranes of the human parasite Leishmania. It is synthesized via two metabolic routes, the de novo pathway that starts with the uptake of choline, and the threefold methylation of phosphatidylethanolamine. Choline was shown to be dispensable for Leishmania; thus, the methylation pathway likely represents the primary route for PC production. Here, we have identified and characterized two phosphatidylethanolamine… Expand
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