Characterization of L-glutamate uptake into and release from astrocytes and neurons cultured from different brain regions

@article{Drejer1982CharacterizationOL,
  title={Characterization of L-glutamate uptake into and release from astrocytes and neurons cultured from different brain regions},
  author={J\orgen Drejer and Orla Miller Larsson and Arne Schousboe},
  journal={Experimental Brain Research},
  year={1982},
  volume={47},
  pages={259-269}
}
The uptake of L-glutamate was studied in astrocytes cultured from different brain areas of newborn rats as well as in two different cultures of neurons obtained from mouse brain. Both astrocytes and neurons exhibited high-affinity glutamate uptake with Km values ranging from 34 [μM to 82 μM. Vmax values for astrocytes cultured from the different brain regions were: prefrontal cortex: 13.9; occipital cortex: 11.4; neostriatum: 27.3 and cerebellum: 5.8 nmol · min−1 · mg−1 cell protein. For… CONTINUE READING
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Astrocytes in primary culture. In: Pfeiffer SE (ed) Neuroscience approached through cell culture

  • L Hertz, BHJ Juurlink, H Fosmark, A Schousboe
  • 1982
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