Characterization of KIBRA, a novel WW domain-containing protein.

  title={Characterization of KIBRA, a novel WW domain-containing protein.},
  author={Joachim Kremerskothen and Christian Plaas and Katrin B{\"u}ther and Indra E Finger and Stefan Veltel and Theodoros Matanis and Thomas Liedtke and Angelika Barnekow},
  journal={Biochemical and biophysical research communications},
  volume={300 4},
In a yeast two hybrid screen with the human isoform of Dendrin (KIAA0749), a putative modulator of the postsynaptic cytoskeleton, we isolated a cDNA coding for a novel protein, KIBRA, possessing two amino-terminal WW domains, an internal C2-like domain and a carboxy-terminal glutamic acid-rich stretch. Northern blot analysis revealed that the expression of KIBRA mRNA was predominately found in kidney and brain. In vitro interaction studies revealed that the first KIBRA WW domain binds… CONTINUE READING

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