Characterization of Imidazoline Receptors in Blood Vessels for the Development of Antihypertensive Agents

@inproceedings{Chen2014CharacterizationOI,
  title={Characterization of Imidazoline Receptors in Blood Vessels for the Development of Antihypertensive Agents},
  author={M F Chen and Jo-Ting Tsai and Li-Jen Chen and Tung-Pi Wu and Jia-Jang Yang and Li-Te Yin and Yulin Yang and T A Chiang and Han-Lin Lu and Ming-Chang Wu},
  booktitle={BioMed research international},
  year={2014}
}
It has been indicated that activation of peripheral imidazoline I2-receptor (I-2R) may reduce the blood pressure in spontaneously hypertensive rats (SHRs). Also, guanidinium derivatives show the ability to activate imidazoline receptors. Thus, it is of special interest to characterize the I-2R using guanidinium derivatives in blood vessels for development of antihypertensive agent(s). Six guanidinium derivatives including agmatine, amiloride, aminoguanidine, allantoin, canavanine, and metformin… CONTINUE READING

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