Characterization of IL-2-induced murine cells which exhibit ADCC activity.

@article{Eisenthal1988CharacterizationOI,
  title={Characterization of IL-2-induced murine cells which exhibit ADCC activity.},
  author={Avi Eisenthal and Eitan Shiloni and Steven A Rosenberg},
  journal={Cellular immunology},
  year={1988},
  volume={115 2},
  pages={257-72}
}
The incubation of murine splenocytes in recombinant interleukin 2 (IL-2) gives rise to both lymphokine-activated killer (LAK) cells capable of lysing fresh tumor cells and cells capable of mediating antibody-dependent cellular cytotoxicity (ADCC) in the presence of anti-H2 allosera. A similarity between these two IL-2-induced cell populations was found. The precursors of the cells mediating these activities were shown to be ASGM1 positive, Thy 1 negative, and radiosensitive. Cells taken from… CONTINUE READING

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