Characterization of Host and Microbial Determinants in Individuals with Latent Tuberculosis Infection Using a Human Granuloma Model

@inproceedings{Guirado2015CharacterizationOH,
  title={Characterization of Host and Microbial Determinants in Individuals with Latent Tuberculosis Infection Using a Human Granuloma Model},
  author={Evelyn Guirado and Uchenna Mbawuike and Tracy L. Keiser and Jes{\'u}s Arcos and Abul Kalam Azad and Shu-hua Wang and Larry S. Schlesinger},
  booktitle={mBio},
  year={2015}
}
UNLABELLED Granulomas sit at the center of tuberculosis (TB) immunopathogenesis. Progress in biomarkers and treatment specific to the human granuloma environment is hindered by the lack of a relevant and tractable infection model that better accounts for the complexity of the host immune response as well as pathogen counterresponses that subvert host immunity in granulomas. Here we developed and characterized an in vitro granuloma model derived from human peripheral blood mononuclear cells… CONTINUE READING
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