Characterization of Heterogeneous Prostate Tumors in Targeted Pten Knockout Mice

Abstract

Previously, we generated a preclinical mouse prostate tumor model based on PSA-Cre driven inactivation of Pten. In this model homogeneous hyperplastic prostates (4-5m) developed at older age (>10m) into tumors. Here, we describe the molecular and histological characterization of the tumors in order to better understand the processes that are associated with… (More)
DOI: 10.1371/journal.pone.0147500

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