Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells

@article{Rodgers2016CharacterizationOH,
  title={Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells},
  author={U. R. Rodgers and Thomas Lanyon-Hogg and N. Masumoto and Markus Ritzefeld and Rosemary Burke and J. Blagg and A. Magee and E. Tate},
  journal={ACS Chemical Biology},
  year={2016},
  volume={11},
  pages={3256 - 3262}
}
The Sonic Hedgehog (Shh) signaling pathway plays a critical role during embryonic development and cancer progression. N-terminal palmitoylation of Shh by Hedgehog acyltransferase (Hhat) is essential for efficient signaling, raising interest in Hhat as a novel drug target. A recently identified series of dihydrothienopyridines has been proposed to function via this mode of action; however, the lead compound in this series (RUSKI-43) was subsequently shown to possess cytotoxic activity unrelated… Expand
20 Citations
Design of Hedgehog pathway inhibitors for cancer treatment
  • 11
Hedgehog signaling pathway inhibitors: an updated patent review (2015–present)
  • 9
Synthesis and Evaluation of Aminothiazole Derivatives as Hedgehog Pathway Inhibitors
Microfluidic Mobility Shift Assay for Real-Time Analysis of Peptide N-Palmitoylation
  • 4
Mechanistic Insights into the Generation and Transduction of Hedgehog Signaling.
  • 10
Sonic Hedgehog signaling pathway in gynecological and genitourinary cancer (Review)
  • PDF
Development of anticancer agents targeting the Hedgehog signaling
  • 12
NKX6-1 mediates cancer stem-like properties and regulates sonic hedgehog signaling in leiomyosarcoma
...
1
2
...

References

SHOWING 1-10 OF 65 REFERENCES
Small molecule modulation of Smoothened activity
  • 876
  • PDF
Stromal response to Hedgehog signaling restrains pancreatic cancer progression
  • 287
  • PDF
Smoothened as a new therapeutic target for human osteosarcoma
  • 91
  • PDF
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
  • 1,154
...
1
2
3
4
5
...