Characterization of Haemophilus ducreyi cdtA, cdtB, and cdtC mutants in in vitro and in vivo systems.

@article{Lewis2001CharacterizationOH,
  title={Characterization of Haemophilus ducreyi cdtA, cdtB, and cdtC mutants in in vitro and in vivo systems.},
  author={David A. Lewis and Megan K Stevens and J. L. Latimer and Christine K. Ward and Kaiping Deng and Robert H. Blick and Sheryl R. Lumbley and Catherine A. Ison and Eric J. Hansen},
  journal={Infection and immunity},
  year={2001},
  volume={69 9},
  pages={5626-34}
}
Haemophilus ducreyi expresses a soluble cytolethal distending toxin (CDT) that is encoded by the cdtABC gene cluster and can be detected in culture supernatant fluid by its ability to kill HeLa cells. The cdtA, cdtB, and cdtC genes of H. ducreyi were cloned independently into plasmid vectors, and their encoded proteins expressed singly or in various… CONTINUE READING