Characterization of Growth-Differentiation Factor 15 , a Transforming Growth Factor b Superfamily Member Induced following Liver Injury

Abstract

We have identified a new murine transforming growth factor b superfamily member, growth-differentiation factor 15 (Gdf15), that is expressed at highest levels in adult liver. As determined by Northern analysis, the expression of Gdf15 in liver was rapidly and dramatically up-regulated following various surgical and chemical treatments that cause acute liver… (More)

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