Characterization of GnRH receptors in bovine pituitary membranes

@article{Hazum1984CharacterizationOG,
  title={Characterization of GnRH receptors in bovine pituitary membranes},
  author={E. Hazum and D. Keinan},
  journal={Molecular and Cellular Endocrinology},
  year={1984},
  volume={35},
  pages={107-111}
}
  • E. Hazum, D. Keinan
  • Published 1984
  • Medicine, Biology
  • Molecular and Cellular Endocrinology
Bovine pituitary gonadotropin-releasing hormone (GnRH) receptors were characterized and identified utilizing a superactive GnRH analog, Buserelin [( D-Ser(t-Bu)6, des-Gly10-ethylamide]-GnRH), and a photoreactive GnRH analog, [azidobenzoyl-D- Lys6 ]-GnRH. Both analogs bind with high affinity to a single class of receptors, with apparent IC50 values of 0.5 nM and 1 nM, respectively. The binding of 125I-labeled Buserelin to pituitary membranes was inhibited, in a dose-responsive manner, by both… Expand
Heifers express G-protein coupled receptor 61 in anterior pituitary gonadotrophs in stage-dependent manner.
Heifers express G-protein coupled receptor 153 in anterior pituitary gonadotrophs in stage-dependent manner.

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