Characterization of Genome-Wide Association-Identified Variants for Atrial Fibrillation in African Americans

  title={Characterization of Genome-Wide Association-Identified Variants for Atrial Fibrillation in African Americans},
  author={Jessica T. Delaney and Janina M. Jeff and Nancy J. Brown and Mias Pretorius and Henry E. Okafor and Dawood Darbar and Dan M. Roden and Dana C. Crawford},
  booktitle={PloS one},
BACKGROUND Despite a greater burden of risk factors, atrial fibrillation (AF) is less common among African Americans than European-descent populations. Genome-wide association studies (GWAS) for AF in European-descent populations have identified three predominant genomic regions associated with increased risk (1q21, 4q25, and 16q22). The contribution of these loci to AF risk in African American is unknown. METHODOLOGY/PRINCIPAL FINDINGS We studied 73 African Americans with AF from the… CONTINUE READING


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