Characterization of G3BPs: tissue specific expression, chromosomal localisation and rasGAP(120) binding studies.

@article{Kennedy2001CharacterizationOG,
  title={Characterization of G3BPs: tissue specific expression, chromosomal localisation and rasGAP(120) binding studies.},
  author={Derek Kennedy and J P French and E Guitard and Kelin Ru and Bruno Tocqu{\'e} and John S. Mattick},
  journal={Journal of cellular biochemistry},
  year={2001},
  volume={84 1},
  pages={173-87}
}
The G3BP (ras-GTPase-Activating Protein SH3-Domain-Binding Protein) family of proteins has been implicated in both signal transduction and RNA-metabolism. We have previously identified human G3BP-1, G3BP-2, and mouse G3BP-2. Here, we report the cloning of mouse G3BP-1, the discovery of two alternatively spliced isoforms of mouse, and human G3BP-2 (G3BP-2a and G3BP-2b), and the chromosomal localisation of human G3BP-1 and G3BP-2, which map to 5q14.2-5q33.3 and 4q12-4q24 respectively. We mapped… CONTINUE READING

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