Characterization of Fibrinogen Binding by Glycoproteins Srr1 and Srr2 of Streptococcus agalactiae*

@inproceedings{Seo2013CharacterizationOF,
  title={Characterization of Fibrinogen Binding by Glycoproteins Srr1 and Srr2 of Streptococcus agalactiae*},
  author={Ho Seong Seo and George Minasov and Ravin Seepersaud and Kelly S. Doran and Ievgeniia Dubrovska and Ludmilla S Shuvalova and Wayne F Anderson and T M Iverson and Paul M Sullam},
  booktitle={The Journal of biological chemistry},
  year={2013}
}
The serine-rich repeat glycoproteins of Gram-positive bacteria comprise a large family of cell wall proteins. Streptococcus agalactiae (group B streptococcus, GBS) expresses either Srr1 or Srr2 on its surface, depending on the strain. Srr1 has recently been shown to bind fibrinogen, and this interaction contributes to the pathogenesis of GBS meningitis. Although strains expressing Srr2 appear to be hypervirulent, no ligand for this adhesin has been described. We now demonstrate that Srr2 also… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Similar Papers

Loading similar papers…