Characterization of FOX-3, an AmpC-type plasmid-mediated beta-lactamase from an Italian isolate of Klebsiella oxytoca.

@article{Marchese1998CharacterizationOF,
  title={Characterization of FOX-3, an AmpC-type plasmid-mediated beta-lactamase from an Italian isolate of Klebsiella oxytoca.},
  author={Anna Marchese and Guillaume Arlet and Gian Carlo Schito and Philippe Henri Lagrange and Alain Philippon},
  journal={Antimicrobial agents and chemotherapy},
  year={1998},
  volume={42 2},
  pages={464-7}
}
Klebsiella oxytoca 1731, which showed a wide spectrum of resistance to beta-lactams, including cefoxitin, was isolated in 1994 from a patient in Genoa, Italy. This strain contained a plasmid-mediated AmpC beta-lactamase with a pI of 7.25. Sequencing of the corresponding DNA of K. oxytoca 1731 revealed 96 and 97% identities of the deduced amino acid sequence with FOX-1 and FOX-2, respectively. 
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