Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues.

@article{Trueb2003CharacterizationOF,
  title={Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues.},
  author={Beat Trueb and Lei Zhuang and Sara Taeschler and Markus Wiedemann},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 36},
  pages={33857-65}
}
Clones for a novel transmembrane receptor termed FGFRL1 were isolated from a subtracted, cartilage-specific cDNA library prepared from chicken sterna. Homologous sequences were identified in other vertebrates, including man, mouse, rat and fish, but not in invertebrates such as Caenorhabditis elegans and Drosophila. FGFRL1 was expressed preferentially in skeletal tissues as demonstrated by Northern blotting and in situ hybridization. Small amounts of the FGFRL1 mRNA were also detected in other… CONTINUE READING
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