Characterization of E3Histone, a novel testis ubiquitin protein ligase which ubiquitinates histones.

@article{Liu2005CharacterizationOE,
  title={Characterization of E3Histone, a novel testis ubiquitin protein ligase which ubiquitinates histones.},
  author={Zhiqian Liu and Rose Oughtred and Simon S Wing},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 7},
  pages={2819-31}
}
During spermatogenesis, a large fraction of cellular proteins is degraded as the spermatids evolve to their elongated mature forms. In particular, histones must be degraded in early elongating spermatids to permit chromatin condensation. Our laboratory previously demonstrated the activation of ubiquitin conjugation during spermatogenesis. This activation is dependent on the ubiquitin-conjugating enzyme (E2) UBC4, and a testis-particular isoform, UBC4-testis, is induced when histones are… CONTINUE READING

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