Characterization of Dystrophin Deficient Rats: A New Model for Duchenne Muscular Dystrophy

  title={Characterization of Dystrophin Deficient Rats: A New Model for Duchenne Muscular Dystrophy},
  author={Thibaut Larcher and Aude Lafoux and Laurent Tesson and S{\'e}verine R{\'e}my and Virginie Th{\'e}penier and Virginie François and Caroline Le Guiner and H{\'e}licia Goubin and Ma{\'e}va Dutilleul and Lydie Guigand and Gilles Toumaniantz and Anne De Cian and Charlotte Boix and Jean-Baptiste Renaud and Yan Ch{\'e}rel and Carine Giovannangeli and Jean Paul Concordet and Ignacio Anegon and Corinne Huchet and Atsushi Asakura},
  booktitle={PloS one},
A few animal models of Duchenne muscular dystrophy (DMD) are available, large ones such as pigs or dogs being expensive and difficult to handle. Mdx (X-linked muscular dystrophy) mice only partially mimic the human disease, with limited chronic muscular lesions and muscle weakness. Their small size also imposes limitations on analyses. A rat model could represent a useful alternative since rats are small animals but 10 times bigger than mice and could better reflect the lesions and functional… CONTINUE READING
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