Characterization of Drosophila tyramine beta-hydroxylase gene and isolation of mutant flies lacking octopamine.

@article{Monastirioti1996CharacterizationOD,
  title={Characterization of Drosophila tyramine beta-hydroxylase gene and isolation of mutant flies lacking octopamine.},
  author={Maria Monastirioti and Charles E. Linn and Kalpana White},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1996},
  volume={16 12},
  pages={3900-11}
}
Octopamine is likely to be an important neuroactive molecule in invertebrates. Here we report the molecular cloning of the Drosophila melanogaster gene, which encodes tyramine beta-hydroxylase (TBH), the enzyme that catalyzes the last step in octopamine biosynthesis. The deduced amino acid sequence of the encoded protein exhibits 39% identity to the evolutionarily related mammalian dopamine beta-hydroxylase enzyme. We generated a polyclonal antibody against the protein product of T beta h gene… CONTINUE READING
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