Characterization of Differential Cocaine Metabolism in Mouse and Rat through Metabolomics-Guided Metabolite Profiling

@article{Yao2013CharacterizationOD,
  title={Characterization of Differential Cocaine Metabolism in Mouse and Rat through Metabolomics-Guided Metabolite Profiling},
  author={D. Yao and Xiao-Lei Shi and L. Wang and Blake A. Gosnell and C. Chen},
  journal={Drug Metabolism and Disposition},
  year={2013},
  volume={41},
  pages={79 - 88}
}
  • D. Yao, Xiao-Lei Shi, +2 authors C. Chen
  • Published 2013
  • Chemistry, Medicine
  • Drug Metabolism and Disposition
  • Rodent animal models have been widely used for studying neurologic and toxicological events associated with cocaine abuse. It is known that the mouse is more susceptible to cocaine-induced hepatotoxicity (CIH) than the rat. However, the causes behind this species-dependent sensitivity to cocaine have not been elucidated. In this study, cocaine metabolism in the mouse and rat was characterized through LC-MS-based metabolomic analysis of urine samples and were further compared through calculating… CONTINUE READING
    31 Citations
    Evaluation of in vitro metabolic systems for common drugs of abuse. 1. Cocaine
    • 2
    Non-targeted metabolomics-guided sildenafil metabolism study in human liver microsomes.
    • 6
    LC–MS-Based Metabolomics in the Study of Drug-Induced Liver Injury
    • 3
    LC-MS-based Metabolomics of Xenobiotic-induced Toxicities
    • C. Chen, S. Kim
    • Biology, Medicine
    • Computational and structural biotechnology journal
    • 2013
    • 20
    • PDF
    LC–MS-based metabolomics: an update
    • 55
    Application of Metabolomics in the Study of Natural Products
    • 7
    • PDF

    References

    SHOWING 1-10 OF 57 REFERENCES
    Studies on metabolic pathways of cocaine and its metabolites using microsome preparations from rat organs.
    • 19
    Cocaine N-demethylation and the metabolism-related hepatotoxicity can be prevented by cytochrome P450 3A inhibitors.
    • 75
    Cocaine-induced hepatic necrosis in mice--the role of cocaine metabolism.
    • 125
    Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic study
    • 52
    Lipidomic profiling reveals protective function of fatty acid oxidation in cocaine-induced hepatotoxicity[S]
    • 28
    • PDF
    Urinary Metabolite Profiling Reveals CYP1A2-Mediated Metabolism of NSC686288 (Aminoflavone)
    • 54
    • PDF
    Role of protein binding in cocaine-induced hepatic necrosis.
    • M. Evans
    • Chemistry, Medicine
    • The Journal of pharmacology and experimental therapeutics
    • 1983
    • 53
    Ion cluster techniques in drug metabolism: use of a mixture of labeled and unlabeled cocaine to facilitate metabolite identification.
    • 16
    Formation of p-hydroxycocaine from cocaine by hepatic microsomes of animals and its pharmacological effects in mice.
    • 11
    Participation of CYP2A in cocaine-induced hepatotoxicity in female mice.
    • 19