Characterization of Differential Cocaine Metabolism in Mouse and Rat through Metabolomics-Guided Metabolite Profiling

  title={Characterization of Differential Cocaine Metabolism in Mouse and Rat through Metabolomics-Guided Metabolite Profiling},
  author={D. Yao and Xiao-Lei Shi and L. Wang and Blake A. Gosnell and C. Chen},
  journal={Drug Metabolism and Disposition},
  pages={79 - 88}
  • D. Yao, Xiao-Lei Shi, +2 authors C. Chen
  • Published 2013
  • Chemistry, Medicine
  • Drug Metabolism and Disposition
  • Rodent animal models have been widely used for studying neurologic and toxicological events associated with cocaine abuse. It is known that the mouse is more susceptible to cocaine-induced hepatotoxicity (CIH) than the rat. However, the causes behind this species-dependent sensitivity to cocaine have not been elucidated. In this study, cocaine metabolism in the mouse and rat was characterized through LC-MS-based metabolomic analysis of urine samples and were further compared through calculating… CONTINUE READING
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