Characterization of Diaphanous-related formin FMNL2 in human tissues

@article{Gardberg2009CharacterizationOD,
  title={Characterization of Diaphanous-related formin FMNL2 in human tissues},
  author={Maria Gardberg and Kati Talvinen and Katja Kaipio and Kristiina Iljin and Caroline Kampf and Mathias Uhl{\'e}n and Olli Carp{\'e}n},
  journal={BMC Cell Biology},
  year={2009},
  volume={11},
  pages={55 - 55}
}
BackgroundDiaphanous-related formins govern actin-based processes involved in many cellular functions, such as cell movement and invasion. Possible connections to developmental processes and cellular changes associated with malignant phenotype make them interesting study targets. In spite of this, very little is known of the tissue distribution and cellular location of any mammalian formin. Here we have carried out a comprehensive analysis of the formin family member formin -like 2 (FMNL2) in… 
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    Results and problems in cell differentiation
  • 2019
TLDR
A growing body of evidence suggests that multiple formin proteins play essential roles in these central cellular processes.
FMNL2/FMNL3 formins are linked with oncogenic pathways and predict melanoma outcome
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A major role for FMNL2/FMNL3 formins in melanoma biology is suggested and the possibility that the novel targeted melanoma drugs may interfere with the cellular properties regulated by these formins is raised.
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