Characterization of Diaphanous-related formin FMNL2 in human tissues

  title={Characterization of Diaphanous-related formin FMNL2 in human tissues},
  author={Maria Gardberg and Kati Talvinen and Katja Kaipio and Kristiina Iljin and Caroline Kampf and Mathias Uhl{\'e}n and Olli Carp{\'e}n},
  journal={BMC Cell Biology},
  pages={55 - 55}
BackgroundDiaphanous-related formins govern actin-based processes involved in many cellular functions, such as cell movement and invasion. Possible connections to developmental processes and cellular changes associated with malignant phenotype make them interesting study targets. In spite of this, very little is known of the tissue distribution and cellular location of any mammalian formin. Here we have carried out a comprehensive analysis of the formin family member formin -like 2 (FMNL2) in… 
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A growing body of evidence suggests that multiple formin proteins play essential roles in these central cellular processes.
FMNL2/FMNL3 formins are linked with oncogenic pathways and predict melanoma outcome
A major role for FMNL2/FMNL3 formins in melanoma biology is suggested and the possibility that the novel targeted melanoma drugs may interfere with the cellular properties regulated by these formins is raised.


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FMNL2 may play an important role in the metastasis of CRC and may be a useful marker for metastasis and real-time RT-PCR analysis confirmed this finding.
Myeloproliferative defects following targeting of the Drf1 gene encoding the mammalian diaphanous related formin mDia1.
Overall, knocking out mDia1 expression in mice leads to a phenotype similar to human myeloproliferative syndrome (MPS) and myelodysplastic syndromes (MDS), which suggest that defective DRF1 expression or mDIA1 function may contribute to myeloid malignancies and point to mD Dia1 as an attractive therapeutic target in MDS and MPS.
Formins in cell signaling.
Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC
A novel regulatory and functional interaction between RhoC and FMNL2 for modulating cell shape and invasiveness is uncovered and mechanistic insight into RHoC-specific signalling events is provided.
Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico.
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The FH2 and N-terminal dimerization domains of FRL2 and FRL3 are able to form hetero-oligomers, unlike other formins, and these data suggest that current models describing DID/DAD autoregulation via steric hindrance of FH1 activity must be revised.
Rho GTPase function in tumorigenesis.
Staying in shape with formins.
Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues
A method for the comparison of mRNA expression levels of most human genes across 9,783 Affymetrix gene expression array experiments representing 43 normal human tissue types, 68 cancer types, and 64 other diseases is developed.