Characterization of Detergent-Insoluble Proteins in ALS Indicates a Causal Link between Nitrative Stress and Aggregation in Pathogenesis

@inproceedings{Basso2009CharacterizationOD,
  title={Characterization of Detergent-Insoluble Proteins in ALS Indicates a Causal Link between Nitrative Stress and Aggregation in Pathogenesis},
  author={Manuela Basso and Giuseppina Samengo and Giovanni Nardo and Tania Massignan and Giuseppina D'Alessandro and Silvia Tartari and L. Garello Cantoni and Marianna Marino and Cristina Cheroni and Silvia De Biasi and Maria Teresa Giordana and Michael J. Strong and Alvaro G. Est{\'e}vez and Mario Salmona and Caterina Bendotti and Valentina Bonetto},
  booktitle={PloS one},
  year={2009}
}
BACKGROUND Amyotrophic lateral sclerosis (ALS) is a progressive and fatal motor neuron disease, and protein aggregation has been proposed as a possible pathogenetic mechanism. However, the aggregate protein constituents are poorly characterized so knowledge on the role of aggregation in pathogenesis is limited. METHODOLOGY/PRINCIPAL FINDINGS We carried out a proteomic analysis of the protein composition of the insoluble fraction, as a model of protein aggregates, from familial ALS (fALS… CONTINUE READING

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