Characterization of DegU, a response regulator in Listeria monocytogenes, involved in regulation of motility and contributes to virulence.

@article{Knudsen2004CharacterizationOD,
  title={Characterization of DegU, a response regulator in Listeria monocytogenes, involved in regulation of motility and contributes to virulence.},
  author={Gitte Maegaard Knudsen and John Elmerdahl Olsen and Lone E. Dons},
  journal={FEMS microbiology letters},
  year={2004},
  volume={240 2},
  pages={171-9}
}
The degU (lmo2515) gene encodes a putative response regulator in the food-borne pathogen Listeria monocytogenes. It has 63% amino acid identity to the DegU response regulator of Bacillus subtilis. We have characterized the degU gene product in L. monocytogenes EGD by generation of a deletion mutant. The DeltadegU mutant was found to be non-motile in motility plate assay and no flagellin was detected. The mutant was attenuated in challenge of mice. Northern blot analysis suggested that the degU… CONTINUE READING