Characterization of DalS, an ATP-binding cassette transporter for D-alanine, and its role in pathogenesis in Salmonella enterica.

@article{Osborne2012CharacterizationOD,
  title={Characterization of DalS, an ATP-binding cassette transporter for D-alanine, and its role in pathogenesis in Salmonella enterica.},
  author={Suzanne E. Osborne and Brian R. Tuinema and Mac C Y Mok and Pui Sai Lau and Nhat Bui and Ana M. Tomljenovic-Berube and Waldemar Vollmer and Kun Zhang and Murray S. Junop and Brian K Coombes},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 19},
  pages={15242-50}
}
Expansion into new host niches requires bacterial pathogens to adapt to changes in nutrient availability and to evade an arsenal of host defenses. Horizontal acquisition of Salmonella Pathogenicity Island (SPI)-2 permitted the expansion of Salmonella enterica serovar Typhimurium into the intracellular environment of host cells by allowing it to deliver bacterial effector proteins across the phagosome membrane. This is facilitated by the SsrA-SsrB two-component regulatory system and a type III… CONTINUE READING
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