Characterization of Chorioamnionitis in 2nd-Trimester C-Section Placentas and Correlation with Microorganism Recovery from Subamniotic Tissues

@article{Hecht2008CharacterizationOC,
  title={Characterization of Chorioamnionitis in 2nd-Trimester C-Section Placentas and Correlation with Microorganism Recovery from Subamniotic Tissues},
  author={Jonathan L. Hecht and Andrew Onderdonk and M Delaney and Elizabeth N. Allred and Harvey J. Kliman and Eduardo V Zambrano and Solveig M.V. Pflueger and Chad Livasy and Ina Bhan and Alan Leviton},
  journal={Pediatric and Developmental Pathology},
  year={2008},
  volume={11},
  pages={15 - 22}
}
Prolonged exposure to infection appears to influence fetal/neonatal development. We characterize the relationship between histologic patterns of inflammation and microorganism recovery from the placentas of live born infants delivered before the 28th postmenstrual week. The subamniotic parenchyma of 835 placentas delivered by cesarean section were cultured and evaluated for specific histologic patterns of inflammation in a blinded fashion. Cases with prolonged membrane rupture were excluded… 
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The results suggest histologic chorioamnionitis at term most often results from a noninfectious inflammatory process, and was strongly associated with fever, most of which was related to epidural used for pain relief.
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The study findings support the association between intra-amniotic infections and preterm delivery and the lower the birth-weight or gestational age, the higher the frequency of silent infections in the uterine cavity.
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Histologic chorioamnionitis as a consideration in the management of newborns of febrile mothers
  • D. Hoang, P. Charlagorla, +4 authors A. Gad
  • Medicine
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2013
TLDR
The HCA in conjunction with an elevated CRP can guide the duration of antimicrobial therapy in infants born to febrile mothers and maternal fever is associated with HCA.
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  • R. Redline
  • Medicine, Biology
    Seminars in fetal & neonatal medicine
  • 2012
Maternal Microbe-Specific Modulation of Inflammatory Response in Extremely Low-Gestational-Age Newborns
TLDR
Evidence that bacterial colonization of the very preterm placenta is associated with distinct microorganism-specific inflammatory protein profiles in the newborn blood specimens is provided, supporting the concept that targeting of placental colonization by specific drugs or probiotics during early pregnancy holds promise for preventing not only preterm birth but also subsequent and long-lasting, inflammation-provoked late sequelae.
Fetal membrane bacterial load is increased in histologically confirmed inflammatory chorioamnionitis: A retrospective cohort study.
Acute chorioamnionitis and intra-amniotic inflammation are more severe according to outside-in neutrophil migration within the same chorio-decidua.
The antecedents and correlates of necrotizing enterocolitis and spontaneous intestinal perforation among infants born before the 28th week of gestation.
TLDR
Maternal and neonatal characteristics might help identify at-risk ELGANs for NEC and SIP, who then may potentially benefit from targeted preventive strategies.
Correlation between Clinical, Placental Histology and Microbiological Findings in Spontaneous Preterm Births
TLDR
Half of the women with PTB had clinical or histological abruption, chorioamnionitis or both, and the main determinant of neonatal outcome was gestational age at delivery and not placental findings.
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References

SHOWING 1-10 OF 41 REFERENCES
Funisitis in term pregnancy is associated with microbial invasion of the amniotic cavity and intra-amniotic inflammation
  • S. Lee, R. Romero, C. Kim, S. Shim, B. Yoon
  • Medicine
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2006
TLDR
Funisitis is present in 4% of women at term and is associated with microbial invasion of the amniotic cavity (MIAC) and inflammation as reflected by increased AF WBC count.
Lack of relationship between histologic chorioamnionitis and duration of the latency period in preterm rupture of membranes.
TLDR
The rate of histologic evidence of chorioamnionitis in preterm PROM does not increase with the duration of the PROM-to-delivery interval, and the prevalence and severity of pathological evidence of intrauterine infection was correlated with the interval between membrane rupture and delivery.
A case‐control study of chorioamnionic infection and histologic chorioamnionitis in prematurity
Acute funisitis of preterm but not term placentas is associated with severe fetal inflammatory response.
TLDR
It is indicated that the robust inflammatory response of the fetus associated with elevated fetal plasma IL-6 level may reflect the biologic needs of the premature fetus to escape from the hostile intrauterine environment.
Histologic chorioamnionitis, microbial infection, and prematurity
The relationship among inflammatory lesions of the umbilical cord (funisitis), umbilical cord plasma interleukin 6 concentration, amniotic fluid infection, and neonatal sepsis.
TLDR
Umbilical cord plasma interleukin 6 concentrations were higher in neonates born with funisitis than in those without this lesion, and this difference remained significant after adjustment for gestational age at birth.
Chorioamnionitis caused by gram-negative bacteria as an etiologic factor in preterm birth
TLDR
The findings suggest that gram-negative enteric rods are important placental pathogens responsible for subclinical chorioamnionitis and possibly preterm birth and the concept that microorganisms ascending from the lower genital tract produce local inflammation, which may result in preterm labour and delivery.
Microbiologic causes and neonatal outcomes associated with chorioamnion infection.
The relationship between acute inflammatory lesions of the preterm placenta and amniotic fluid microbiology.
The prevalence and distribution of acute placental inflammation in uncomplicated term pregnancies
...
1
2
3
4
5
...