Characterization of CYPs and UGTs Involved in Human Liver Microsomal Metabolism of Osthenol

  title={Characterization of CYPs and UGTs Involved in Human Liver Microsomal Metabolism of Osthenol},
  author={P. Cho and Sanjita Paudel and Doohyun Lee and Yun Ji Jin and GeunHyung Jo and T. Jeong and Sangkyu Lee and Taeho Lee},
Osthenol is a prenylated coumarin isolated from the root of Angelica koreana and Angelica dahurica, and is an O-demethylated metabolite of osthole in vivo. Its various pharmacological effects have been reported previously. The metabolic pathway of osthenol was partially confirmed in rat osthole studies, and 11 metabolic products were identified in rat urine. However, the metabolic pathway of osthenol in human liver microsomes (HLM) has not been reported. In this study, we elucidated the… Expand
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  • Chemistry, Medicine
  • Xenobiotica; the fate of foreign compounds in biological systems
  • 2012
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  • Chemistry, Medicine
  • Journal of pharmaceutical and biomedical analysis
  • 2013
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A coumarin-specific prenyltransferase catalyzes the crucial biosynthetic reaction for furanocoumarin formation in parsley.
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