Characterization of COX17, a yeast gene involved in copper metabolism and assembly of cytochrome oxidase.

@article{Glerum1996CharacterizationOC,
  title={Characterization of COX17, a yeast gene involved in copper metabolism and assembly of cytochrome oxidase.},
  author={D. Moira Glerum and Andrey Shtanko and Alexander Tzagoloff},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 24},
  pages={14504-9}
}
Mutations in the COX17 gene of Saccharomyces cerevisiae cause a respiratory deficiency due to a block in the production of a functional cytochrome oxidase complex. Because cox17 mutants are able to express both the mitochondrially and nuclearly encoded subunits of cytochrome oxidase, the Cox17p most likely affects some late posttranslational step of the assembly pathway. A fragment of yeast nuclear DNA capable of complementing the mutation has been cloned by transformation of the cox17 mutant… CONTINUE READING

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