Characterization of COR627 and COR628, Two Novel Positive Allosteric Modulators of the GABAB Receptor

@article{Castelli2012CharacterizationOC,
  title={Characterization of COR627 and COR628, Two Novel Positive Allosteric Modulators of the GABAB Receptor},
  author={Maria Paola Castelli and Angelo Casu and Paola Casti and Carla Lobina and Mauro A. M. Carai and Giancarlo Colombo and Maurizio Solinas and Daniela Giunta and Claudia Mugnaini and Serena Pasquini and Andrea Tafi and Simone Brogi and Gian Luigi Gessa and Federico Corelli},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2012},
  volume={340},
  pages={529 - 538}
}
The potential efficacy of GABAB receptor agonists in the treatment of pain, drug addiction, epilepsy, cognitive dysfunctions, and anxiety disorders is supported by extensive preclinical and clinical evidence. However, the numerous side effects produced by the GABAB receptor agonist baclofen considerably limit the therapeutic use of this compound. The identification of positive allosteric modulators (PAMs) of the GABAB receptor may constitute a novel approach in the pharmacological manipulation… Expand
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  • Medicine, Chemistry
  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2020
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