Characterization of CLL exosomes reveals a distinct microRNA signature and enhanced secretion by activation of BCR signaling.

@article{Yeh2015CharacterizationOC,
  title={Characterization of CLL exosomes reveals a distinct microRNA signature and enhanced secretion by activation of BCR signaling.},
  author={Yuh-Ying Yeh and H. Ozer and A. Lehman and K. Maddocks and L. Yu and A. Johnson and J. Byrd},
  journal={Blood},
  year={2015},
  volume={125 21},
  pages={
          3297-305
        }
}
Multiple studies show that chronic lymphocytic leukemia (CLL) cells are heavily dependent on their microenvironment for survival. Communication between CLL cells and the microenvironment is mediated through direct cell contact, soluble factors, and extracellular vesicles. Exosomes are small particles enclosed with lipids, proteins, and small RNAs that can convey biological materials to surrounding cells. Our data herein demonstrate that CLL cells release significant amounts of exosomes in… Expand
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