Characterization of CLL exosomes reveals a distinct microRNA signature and enhanced secretion by activation of BCR signaling.

@article{Yeh2015CharacterizationOC,
  title={Characterization of CLL exosomes reveals a distinct microRNA signature and enhanced secretion by activation of BCR signaling.},
  author={Yuh-Ying Yeh and Hatice Gulcin Ozer and Amy M. Lehman and Kami Maddocks and Lianbo Yu and Amy J. Johnson and John C. Byrd},
  journal={Blood},
  year={2015},
  volume={125 21},
  pages={
          3297-305
        }
}
  • Yuh-Ying Yeh, Hatice Gulcin Ozer, +4 authors John C. Byrd
  • Published in Blood 2015
  • Medicine, Biology
  • Multiple studies show that chronic lymphocytic leukemia (CLL) cells are heavily dependent on their microenvironment for survival. Communication between CLL cells and the microenvironment is mediated through direct cell contact, soluble factors, and extracellular vesicles. Exosomes are small particles enclosed with lipids, proteins, and small RNAs that can convey biological materials to surrounding cells. Our data herein demonstrate that CLL cells release significant amounts of exosomes in… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 75 REFERENCES

    The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: 3304 YEH et al BLOOD

    • AK Ghosh, C Secreto, J Boysen
    • MAY 2015 x VOLUME 125,
    • 2017

    Hypoxiainducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

    • T Wang, DM Gilkes, N Takano
    • Proc Natl Acad Sci USA
    • 2014