Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes.

@article{Murao1997CharacterizationOC,
  title={Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes.},
  author={Kazutoshi Murao and Victor J. Terpstra and Simone R. Green and N. F. Kondratenko and Daniel Steinberg and Oswald Quehenberger},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 28},
  pages={17551-7}
}
Recently, a murine scavenger receptor type B class I (SR-BI) was identified that binds high density lipoprotein (HDL) and mediates the selective uptake of cholesterol esters. The human CD36 and LIMPII analogous-1 (CLA-1) receptor shows high sequence homology with SR-BI, but their functional relationship has not been determined. Transfected cells expressing CLA-1 bound HDL with a Kd of about 35 microg/ml, similar to the Kd for HDL binding to rodent SR-BI. This binding resulted in an… CONTINUE READING

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