Characterization of CD44v6 isoforms in head-and-neck squamous-cell carcinoma.

@article{Hal1999CharacterizationOC,
  title={Characterization of CD44v6 isoforms in head-and-neck squamous-cell carcinoma.},
  author={N L van Hal and Guus Ams van Dongen and Marijke Stigter-van Walsum and Gordon B J Snow and Ruud H. Brakenhoff},
  journal={International journal of cancer},
  year={1999},
  volume={82 6},
  pages={
          837-45
        }
}
CD44 splice variants, especially those containing the v6 domain, are assumed to play a critical role in the malignant progression of many human tumors. This concept was based on (i) the aberrant expression of CD44v6 in malignant cells, often encoded by alternatively spliced transcripts, and (ii) the absence of CD44v6 expression in corresponding normal tissues. Remarkably, data on CD44v6 expression in squamous cells do not support this hypothesis: the v6 domain is highly expressed in normal… CONTINUE READING
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