Characterization of Bglu3, a mouse fasting glucose locus, and identification of Apcs as an underlying candidate gene.

@article{Li2012CharacterizationOB,
  title={Characterization of Bglu3, a mouse fasting glucose locus, and identification of Apcs as an underlying candidate gene.},
  author={Jing Li and Zongji Lu and Qian Wang and Zhiguang Su and Yongde Bao and Weibin Shi},
  journal={Physiological genomics},
  year={2012},
  volume={44 6},
  pages={345-51}
}
Bglu3 is a quantitative trait locus for fasting glucose on distal chromosome 1 identified in an intercross between C57BL/6 (B6) and C3H/HeJ (C3H) apolipoprotein E-deficient (apoE(-/-)) mice. This locus was subsequently replicated in two separate mouse intercrosses. The objective of this study was to characterize Bglu3 through construction and analysis of a congenic strain and identify underlying candidate genes. Congenic mice were constructed by introgressing a genomic region harboring Bglu3… CONTINUE READING
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