Characterization of Bacillus subtilis DSM704 and its production of 1-deoxynojirimycin.

  title={Characterization of Bacillus subtilis DSM704 and its production of 1-deoxynojirimycin.},
  author={D. C. Stein and Leslie K Kopec and Ronald E. Yasbin and Frank E. Young},
  journal={Applied and environmental microbiology},
  volume={48 2},
A Bacillus subtilis strain, DSM704, was characterized by genetic means, and its production of a human intestinal sucrase inhibitor, 1-deoxynojirimycin, was described. Synthesis of this compound is detected concomitant with the detection of heat-resistant spores. The amount of 1-deoxynojirimycin produced is highly dependent on the carbon source, with growth on substrates metabolized via glycolysis giving the greatest amount of production (up to 1 mg/ml). 1-Deoxynojirimycin appears to be… CONTINUE READING
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