Characterization of B cells in severe combined immunodeficiency disease.

  title={Characterization of B cells in severe combined immunodeficiency disease.},
  author={Trudy N. Small and C. A. Keever and Nancy H. Collins and Bryony Dupont and Richard J O'reilly and Neal Flomenberg},
  journal={Human immunology},
  volume={25 3},
The circulating lymphoid cells of eight consecutive untreated infants with severe combined immunodeficiency disease (SCID) with B cells were analyzed for surface marker expression and function. The B cells of these children expressed sIg, HLA-DR, CD19 (B4), CD20 (B1), CD21 (B2), Leu-8, and lacked expression of CD10 (CALLA), as do normal peripheral blood B lymphocytes. SCID B cells also expressed antigens that are normally absent or present on only a minor subset of circulating adult B… CONTINUE READING

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