Characterization of Alkylating Versus Intercalating Anticancer Drug-Induced Effects on Cell Survival, Cell Cycle Kinetic and Morphonuclear Pattern of Three Neoplastic Cells Lines Growing in Vitro

@article{Pauwels1995CharacterizationOA,
  title={Characterization of Alkylating Versus Intercalating Anticancer Drug-Induced Effects on Cell Survival, Cell Cycle Kinetic and Morphonuclear Pattern of Three Neoplastic Cells Lines Growing in Vitro},
  author={Olivier S. G. Pauwels and R{\'o}bert Kiss and J. -L. Pasteels and Ghanem Atassi},
  journal={Pharmaceutical Research},
  year={1995},
  volume={12},
  pages={1011-1018}
}
Purpose. The influence of three alkylating and three intercalating anticancer drugs on cell survival, cell cycle kinetics and chromatin patterns was monitored in vitro on three neoplastic cell lines. Methods. This monitoring was carried out by means of the digital cell image analysis of Feulgen-stained nuclei. Results. Results show that in term of… CONTINUE READING