Characterization of AZD4694, a novel fluorinated Abeta plaque neuroimaging PET radioligand.

@article{Jurus2010CharacterizationOA,
  title={Characterization of AZD4694, a novel fluorinated Abeta plaque neuroimaging PET radioligand.},
  author={Anders Jur{\'e}us and Britt-Marie Swahn and Johan Sandell and Fredrik Jeppsson and Allan E Johnson and Peter Johnstr{\"o}m and Jan A. M. Neelissen and Dan Sunnemark and Lars Farde and Samuel P. S. Svensson},
  journal={Journal of neurochemistry},
  year={2010},
  volume={114 3},
  pages={784-94}
}
Positron emission tomography (PET) radioligands that bind selectively to beta-amyloid plaques (Abeta) are promising imaging tools aimed at supporting the diagnosis of Alzheimer's disease and the evaluation of new drugs aiming to modify amyloid plaque load. For extended clinical use, there is a particular need for PET tracers labeled with fluorine-18, a radionuclide with 110 min half-life allowing for central synthesis followed by wide distribution. The development of fluorinated radioligands is… CONTINUE READING