Characterization of ATP-sensitive potassium channel-blocking activity of ZENECA ZM181,037, a eukalemic diuretic.

@article{Kau1994CharacterizationOA,
  title={Characterization of ATP-sensitive potassium channel-blocking activity of ZENECA ZM181,037, a eukalemic diuretic.},
  author={S. Kau and P. Zografos and M. Do and T. Halterman and M. McConville and C. Yochim and S. Trivedi and Burton B. Howe and J. Li},
  journal={Pharmacology},
  year={1994},
  volume={49 4},
  pages={
          238-48
        }
}
  • S. Kau, P. Zografos, +6 authors J. Li
  • Published 1994
  • Chemistry, Medicine
  • Pharmacology
  • ZENECA ZM181,037 is a novel eukalemic diuretic from a series of 1,1-diarylcarbin-1-01-2 amines. In contrast to the standard diuretic hydrochlorothiazide, the blood pressure-lowering effect was not observed with ZENECA ZM181,037 in spontaneously hypertensive rats. ZENECA ZM181,037 demonstrated a K+ channel-blocker profile. In the isolated rat aorta stimulated with 20 mmol/l KCl, both the d- and l-enantiomer of ZENECA ZM181,037 antagonized the relaxation of cromakalim with mean pKB values of 6.4… CONTINUE READING
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