Characterization of ATP-independent ERK inhibitors identified through in silico analysis of the active ERK2 structure.

@article{Chen2006CharacterizationOA,
  title={Characterization of ATP-independent ERK inhibitors identified through in silico analysis of the active ERK2 structure.},
  author={Fengming Chen and Chad N Hancock and Alba T. Macias and Joseph Joh and Kimberly Still and Shijun Zhong and Alexander D MacKerell and Paul Shapiro},
  journal={Bioorganic & medicinal chemistry letters},
  year={2006},
  volume={16 24},
  pages={6281-7}
}
The extracellular signal-regulated kinases (ERK1 and ERK2) are important mediators of cell proliferation. Constitutive activation of the ERK proteins plays a critical role in the proliferation of many human cancers. Taking advantage of recently identified substrate docking domains on ERK2, we have used computer-aided drug design (CADD) to identify novel low molecular weight compounds that interact with ERK2 in an ATP-independent manner and disrupt substrate-specific interactions. In the current… CONTINUE READING

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