Characterization of ANIT-induced toxicity using precision-cut rat and dog liver slices cultured in a dynamic organ roller system.

@article{Amin2006CharacterizationOA,
  title={Characterization of ANIT-induced toxicity using precision-cut rat and dog liver slices cultured in a dynamic organ roller system.},
  author={K Amin and C Ip and B Sato and T Le and C E Green and Charles A. Tyson and H P Behrsing},
  journal={Toxicologic pathology},
  year={2006},
  volume={34 6},
  pages={776-84}
}
  • K Amin, C Ip, +4 authors H P Behrsing
  • Published 2006 in Toxicologic pathology
This article describes the toxicity of alpha-naphthylisothiocyanate (ANIT), a compound known to induce dose-dependent hepatobiliary toxicity in vivo, using the slice model. Liver slices (200 microm thick) from male Sprague-Dawley rats and male beagle dogs were cultured for 7 days while exposed to a range of ANIT concentrations (1- 100 microM for rat and 4-320 microM for dog). Tissues (and medium for dog) were evaluated using a panel of clinically relevant biomarkers for liver and histological… CONTINUE READING

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