Characterization of 5-hydroxytryptamine receptors mediating circular smooth muscle contraction in the human umbilical artery.

@article{Karlsson1999CharacterizationO5,
  title={Characterization of 5-hydroxytryptamine receptors mediating circular smooth muscle contraction in the human umbilical artery.},
  author={Christina Karlsson and Gunilla Bodelsson and Mikael Bodelsson and Martin Stjernquist},
  journal={Gynecologic and obstetric investigation},
  year={1999},
  volume={47 2},
  pages={102-7}
}
The study was performed to characterize pharmacologically the contractile 5-hydroxytryptamine (5-HT) receptors in the circular smooth muscle of the isolated human umbilical artery. Effects of agonists and antagonists for different 5-HT receptor subtypes were studied in intact endothelium vessel segments. All agonists induced concentration-dependent circular smooth muscle contractions. The potency was in declining order 5-HT > alpha-methyl-5-HT > sumatriptan >/= 2-methyl-5-HT. The effects of 5… CONTINUE READING

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