Characterization of 5-HT receptors in the parasitic nematode, Ascaris suum.

@article{Trim2001CharacterizationO5,
  title={Characterization of 5-HT receptors in the parasitic nematode, Ascaris suum.},
  author={Julie E Trim and Lindy Holden-Dye and James Willson and Michael J Lockyer and Robert J. Walker},
  journal={Parasitology},
  year={2001},
  volume={122 Pt 2},
  pages={207-17}
}
The pharmacological profiles of the 5-hydroxytryptamine (5-HT) receptors on Ascaris suum pharyngeal and somatic body wall muscles were investigated. The mechanisms involved following activation of these receptors were also studied. 5-HT activated and maintained pumping in isolated pharynxes with an EC-50 value of 44+/-1.7 microM. The 5-HT agonists, tryptamine, sumatriptan 8-OH-DPAT and 5-carboxyamidotryptamine all failed to stimulate pumping. The 5-HT2 antagonist, ketanserin, initially excited… CONTINUE READING